Role of drebrin A in dendritic spine plasticity and synaptic function: Implications in neurological disorders.

@article{Ivanov2009RoleOD,
  title={Role of drebrin A in dendritic spine plasticity and synaptic function: Implications in neurological disorders.},
  author={Anton I. Ivanov and Monique Esclapez and Lotfi Ferhat},
  journal={Communicative & integrative biology},
  year={2009},
  volume={2 3},
  pages={268-70}
}
Drebrin A is one of the most abundant neuron-specific binding proteins of F-actin and its expression is increased in parallel with synapse formation. Drebrin A is particularly concentrated in dendritic spines, postsynaptic sides of excitatory glutamatergic synapses. More recently, Ferhat and colleagues reported the functional role of drebrin A in regulating synaptic transmission. Indeed, our study showed that overexpression of drebrin A induced an increase of glutamatergic but not GABAergic… CONTINUE READING
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