Role of dopaminergic and serotonergic systems on behavioral stimulatory effects of low-dose alprazolam and lorazepam

  title={Role of dopaminergic and serotonergic systems on behavioral stimulatory effects of low-dose alprazolam and lorazepam},
  author={D. Bentu{\'e}-Ferrer and J. M. Reymann and O. Tribut and H. Allain and M. Bourin},
  journal={European Neuropsychopharmacology},
  • D. Bentué-Ferrer, J. M. Reymann, +2 authors M. Bourin
  • Published 2001
  • Psychology, Medicine
  • European Neuropsychopharmacology
  • Several recent studies have demonstrated that alprazolam and lorazepam, administered at low doses to healthy volunteers, improve cognitive functions and psychomotor performances. Paradoxical effects of low-dose benzodiazepines have been also observed in mice, in experimental pharmacology. The aim of this work was to determine, in rat, the effect of similar low-doses of benzodiazepines on spontaneous locomotor activity and performance in the elevated zero-maze, and to investigate the underlying… CONTINUE READING
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