Role of dopaminergic and serotonergic systems on behavioral stimulatory effects of low-dose alprazolam and lorazepam

  title={Role of dopaminergic and serotonergic systems on behavioral stimulatory effects of low-dose alprazolam and lorazepam},
  author={Dani{\`e}le Bentu{\'e}‐Ferrer and Jean Michel Reymann and Olivier Tribut and Herv{\'e} Allain and Eero Vasar and Michel Bourin},
  journal={European Neuropsychopharmacology},

Oxidative metabolism of limbic structures after acute administration of diazepam, alprazolam and zolpidem

Electrophysiological effects of allopregnanolone in rats with a history of ethanol exposure.

It is suggested that increased sensitivity to ALLO's neurobehavioral effects is limited to the early phases of EtOH withdrawal and may not extend to more protracted periods of abstinence.

Anxiolytic activity of Angiotensin-Receptor-Blocker in Experimental Models of Anxiety in Mice

Candelesartan may prove to be a useful remedy for the management of anxiety owing to its neuroprotective and antioxidant activity.

Diazepam Inhibits Electrically Evoked and Tonic Dopamine Release in the Nucleus Accumbens and Reverses the Effect of Amphetamine.

The findings challenge the classic view that all drugs of abuse cause dopamine release in the nucleus accumbens and suggest that benzodiazepines could be useful in the treatment of addiction to other drugs that increase the level of dopamine release, such as cocaine, amphetamines, and nicotine.

Availability of the serotonin transporter in patients with alcohol dependence

  • Pei-Shen HoMei-Chen Shih San-Yuan Huang
  • Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2011
It is suggested that pure alcoholics may have lower Sert availability in the midbrain; the 5HTTLPR polymorphism may influence SERT availability in ANX/DEP ALC.

Diazepam Concurrently Increases the Frequency and Decreases the Amplitude of Transient Dopamine Release Events in the Nucleus Accumbens

Diazepam increases the frequency of accumbal dopamine release events by disinhibiting dopamine neurons, but also decreases their amplitude, and it is speculated that the modest abuse liability of benzodiazepines is due to their ability to decrease the amplitude of dopamine release Events in addition to increasing their frequency.



Low-dose alprazolam augments motor activity in mice

Comparison of behavioral effects after single and repeated administrations of four benzodiazepines in three mice behavioral models.

The results suggest that the behavioral profile of benzodiazepines may not be identical during acute and chronic treatment and differences may be present in clinical treatment and warrant investigation in humans.

Effects of midazolam and flunitrazepam on the release of dopamine from rat striatum measured by in vivo microdialysis.

The results suggest that midazolam and flunitrazepam affect striatal dopamine release in a different manner.

Benzodiazepine Receptor Binding of Triazolobenzodiazepines In Vivo: Increased Receptor Number with Low‐Dose Alprazolam

In vivo receptor binding, as defined by the specific uptake of [3H]Ro 15–1788, decreased with increasing doses of estazolam and triazol am, a finding indicating dose‐related increases in receptor occupancy due to these compounds, but alprazolam appears to be anomalous in that low brain concentrations increase benzodiazepine receptor number.

The effect of acute and chronic diazepam treatment on stress-induced changes in cortical dopamine in the rat

Effects of low doses of lorazepam on psychometric tests in healthy volunteers

It is suggested that low repeated doses of lorazepam in healthy subjects improve the psychomotor performance without sedation and memory impairment.