Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies.

@article{Volkow2002RoleOD,
  title={Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies.},
  author={Nora D. Volkow and Joanna S. Fowler and Gene Jack Wang and Yu Ding and Samuel John Gatley},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2002},
  volume={12 6},
  pages={557-66}
}
Methylphenidate is the most commonly prescribed drug for the treatment of ADHD. We have used positron emission tomography to assess the role that methylphenidate's effects in brain dopamine have on its therapeutic and reinforcing effects. We have documented that in the human brain therapeutic doses of methylphenidate block more than 50% of the dopamine transporters and significantly enhance extracellular DA, an effect that appears to be modulated by the rate of DA release. Thus, we postulate… CONTINUE READING

From This Paper

Topics from this paper.
70 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 70 extracted citations

Similar Papers

Loading similar papers…