Role of dopamine in prepulse inhibition of acoustic startle

  title={Role of dopamine in prepulse inhibition of acoustic startle},
  author={Jianhua Zhang and Christian Forkstam and J{\"o}rgen A. Engel and Lennart Svensson},
Rationale: Prepulse inhibition of acoustic startle is the reduction in startle response to an intense auditory stimulus when this stimulus is immediately preceded by a weaker prestimulus. Prepulse inhibition occurs normally in humans and experimental animals, but schizophrenic persons often exhibit a marked impairment in this measure. Previous studies have shown that dopamine (DA)-dependent neuronal mechanisms are involved in the modulation of prepulse inhibition. Objective: Experiments were… CONTINUE READING


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