Role of dopamine D1-family receptors in dorsolateral striatum in context-induced reinstatement of heroin seeking in rats

@article{Bossert2009RoleOD,
  title={Role of dopamine D1-family receptors in dorsolateral striatum in context-induced reinstatement of heroin seeking in rats},
  author={Jennifer M Bossert and Kristina A. Wihbey and Charles L. Pickens and Sunila G. Nair and Yavin Shaham},
  journal={Psychopharmacology},
  year={2009},
  volume={206},
  pages={51-60}
}
In humans, exposure to environmental contexts previously associated with heroin intake can provoke relapse to drug use. In rats, exposure to heroin-associated contexts after extinction of drug-reinforced responding in different contexts reinstates heroin seeking. This effect is attenuated by blockade of D1-family receptors in lateral or medial accumbens shell, but not accumbens core. In this study, we further characterized the role of striatal D1-family receptors in context-induced… CONTINUE READING