Role of dihydrotestosterone in androgen action

@article{Wilson1996RoleOD,
  title={Role of dihydrotestosterone in androgen action},
  author={Jean D. Wilson},
  journal={The Prostate},
  year={1996},
  volume={29}
}
Androgen action differs from that of most hormones in that testosterone, the major androgen secreted from the testes and the most abundant androgen in the circulation of men, is not the principal androgen within target cells. Indeed, abundant evidence indicates that most androgen actions are mediated by the 5α‐reduced metabolite dihydrotestosterone that is formed in target tissues. The conversion of testosterone to dihydrotestosterone is mediated by two isoenzymes; mutations in the steroid 5… 

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...

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