Role of different regions of alpha-synuclein in the assembly of fibrils.

@article{Qin2007RoleOD,
  title={Role of different regions of alpha-synuclein in the assembly of fibrils.},
  author={Zhijie Qin and Dongmei Hu and Shubo Han and Dong-Pyo Hong and Anthony L. Fink},
  journal={Biochemistry},
  year={2007},
  volume={46 46},
  pages={
          13322-30
        }
}
Elucidating the details of the assembly of amyloid fibrils is a key step to understanding the mechanism of amyloid deposition diseases including Parkinson's disease. Although several models have been proposed, based on analyses of polypeptides and short peptides, a detailed understanding of the structure and mechanism of alpha-synuclein fibrillation remains elusive. In this study, we used trypsin and endoproteinase GluC to digest intact alpha-synuclein fibrils and to analyze the detailed… CONTINUE READING

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