Role of dentate gyrus alterations in mesial temporal sclerosis.

  title={Role of dentate gyrus alterations in mesial temporal sclerosis.},
  author={Gianluca Marucci and Guido Rubboli and Marco Giulioni},
  journal={Clinical neuropathology},
  volume={29 1},
Drug-resistant chronic temporal lobe epilepsy is the most common type of epilepsy that undergoes surgical treatment. To verify if dentate gyrus alterations may play a role in patients with mesial temporal sclerosis (MTS), 14 patients, submitted to epilepsy surgery, were selected. Only cases with MTS alone were included. Granule cell dispersion (GCD) was observed in 7 cases (50%). A statistically significant correlation between GCD and the mean number of seizures/month was evidenced. The… CONTINUE READING


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