Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans.

@article{Osterholzer2009RoleOD,
  title={Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans.},
  author={John J. Osterholzer and Jami E. Milam and Gwo-hsiao Chen and Galen B. Toews and Gary B Huffnagle and Michal A Olszewski},
  journal={Infection and immunity},
  year={2009},
  volume={77 9},
  pages={3749-58}
}
Successful pulmonary clearance of the encapsulated yeast Cryptococcus neoformans requires a T1 adaptive immune response. This response takes up to 3 weeks to fully develop. The role of the initial, innate immune response against the organism is uncertain. In this study, an established model of diphtheria toxin-mediated depletion of resident pulmonary dendritic cells (DC) and alveolar macrophages (AM) was used to assess the contribution of these cells to the initial host response against… CONTINUE READING
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