Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma.

@article{Vermi2006RoleOD,
  title={Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma.},
  author={William Vermi and Fabio F. Facchetti and Elena Riboldi and Holger Heine and Sara Scutera and Sarah Stornello and Daniela Ravarino and Paola Cappello and Mirella Giovarelli and Raffaele Badolato and Mario Zucca and Francesca Gentili and Marco Chilosi and Claudio Doglioni and Alessandro Negro Ponzi and Silvano Sozzani and Tiziana Musso},
  journal={Blood},
  year={2006},
  volume={107 2},
  pages={454-62}
}
Dendritic cells (DCs) initiate adaptive immunity and regulate the inflammatory response by producing inflammatory chemokines. This study was aimed to elucidate their role in the pathogenesis of the suppurative granuloma induced by Bartonella henselae infection, which characterizes cat scratch disease (CSD). In vitro DC infection by B. henselae results in internalization of bacteria, phenotypic maturation with increased expression of HLA-DR and CD86, and induction of CD83, CD208, and CCR7. In… CONTINUE READING
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