Role of delta-aminolevulinic acid in the symptoms of acute porphyria.

  title={Role of delta-aminolevulinic acid in the symptoms of acute porphyria.},
  author={Daniel M. Bissell and Jennifer C. Lai and Raymond K Meister and Paul David Blanc},
  journal={The American journal of medicine},
  volume={128 3},
BACKGROUND Attacks of neuropathic pain, usually abdominal, are characteristic of the acute porphyrias and accompanied by overproduction of heme-precursor molecules, specifically delta-aminolevulinic acid and porphobilinogen. The basis for the acute symptoms in these diseases has been speculative. METHODS We review genetic acute porphyria, hereditary tyrosinemia, and an acquired condition, lead poisoning. All perturb heme synthesis and present with a similar pain syndrome. RESULTS Although… CONTINUE READING
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