Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance.

@article{Zhang2006RoleOD,
  title={Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance.},
  author={Xu Zhang and Lan Bao and Ji-Song Guan},
  journal={Trends in pharmacological sciences},
  year={2006},
  volume={27 6},
  pages={324-9}
}
Changes in the number of receptors on the cell surface lead to modulations of physiological functions and pharmacological responses of neurons. Recent studies show that delta-opioid peptide (DOP) and mu-opioid peptide (MOP) receptors have distinct subcellular localizations in neurons. In nociceptive small neurons in the dorsal root ganglia, DOP receptors are sorted into neuropeptide-containing secretory vesicles, enabling the stimulus-induced cell surface expression of these receptors. MOP… CONTINUE READING