Role of cytotoxic protease granzyme-b in neuronal degeneration during human stroke.

Abstract

Infiltration of leukocytes into post-ischemic cerebrum is a well-described phenomenon in stroke injury. Because CD-8(+) T-lymphocytes secrete cytotoxic proteases, including granzyme-b (Gra-b) that exacerbates post-ischemic brain damage, we investigated roles of Gra-b in human stroke. To study the role of Gra-b in stroke, ischemic and non-ischemic tissues… (More)
DOI: 10.1111/j.1750-3639.2010.00426.x

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