Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis.

Abstract

The aim of our study was to evaluate the role of proinflammatory cytokines: tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), as well as the possible contribution of interleukin-10 (IL-10) in anemia of chronic disease (ACD) of rheumatoid arthritis (RA) patients. We measured the serum levels of TNFalpha, IL-1beta, and IL-6 in 105 anemic and 127 nonanemic RA patients. We also investigated the effects of the above cytokines on the development of burst-forming units-erythroid (BFUe) and colony-forming units-erythroid (CFUe) in bone marrow cultures. Anemic patients had significantly higher serum levels of TNFalpha, IL-1beta, and IL-6 compared to nonanemics. Serum IL-10 levels were low and there was no significant difference in IL-10 concentrations between anemic and nonanemic patients. Proinflammatory cytokines inhibited proliferation of BFUe and CFUe. IL-10 did not decrease the erythroid colony growth. Proinflammatory cytokines may play a role in the pathogenesis of ACD in RA patients. Low levels of IL-10 possibly contribute to the development of ACD.

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@article{Voulgari1999RoleOC, title={Role of cytokines in the pathogenesis of anemia of chronic disease in rheumatoid arthritis.}, author={Paraskevi V. Voulgari and G Kolios and George K. Papadopoulos and Afroditi Katsaraki and Konstantinos I Seferiadis and Alexandros A. Drosos}, journal={Clinical immunology}, year={1999}, volume={92 2}, pages={153-60} }