Role of cytokines in the lipopolysaccharide-evoked depression of cytochrome P450 in the brain and liver.

@article{Nicholson2001RoleOC,
  title={Role of cytokines in the lipopolysaccharide-evoked depression of cytochrome P450 in the brain and liver.},
  author={Tara E. Nicholson and Kenneth W. Renton},
  journal={Biochemical pharmacology},
  year={2001},
  volume={62 12},
  pages={
          1709-17
        }
}
A role for cytokines as mediators of the depression in cytochrome P450 activity in brain and liver during CNS inflammation is proposed. Lipopolysaccharide (LPS) was given directly into the lateral ventricle of the brain to mimic a localized CNS infection. CYP1A activity and protein in both brain and liver were depressed in response to this treatment. The administration of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interferon-gamma… CONTINUE READING

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