Role of cytokines and inflammatory mediators in tissue destruction.

  title={Role of cytokines and inflammatory mediators in tissue destruction.},
  author={Henning Birkedal-Hansen},
  journal={Journal of periodontal research},
  volume={28 6 Pt 2},
Colonization or emergence of microbial pathogens may result in tissue destruction by activation of one or more of five distinct host degradative pathways (matrix metalloproteinase pathway, plasminogen-dependent pathway, phagocytic pathway, PMN-serine proteinase pathway and osteoclastic bone resorption) or by direct cleavage of extracellular matrix constituents by microbial proteinases. Activation of endogenous destructive pathways may be mediated by immune responses resulting in expression of… CONTINUE READING