Role of cytokines and chemokines in idiopathic inflammatory myopathies.

  title={Role of cytokines and chemokines in idiopathic inflammatory myopathies.},
  author={Boel De Paepe and Kim K. Creus and Jan L. De Bleecker},
  journal={Current opinion in rheumatology},
  volume={21 6},
PURPOSE OF REVIEW Cytokines and chemokines are essential players in the initiation and progression of the idiopathic inflammatory myopathies (IIMs). This review focuses on the most recent data and the new insight they provide for the disease mechanisms of dermatomyositis, polymyositis and sporadic inclusion body myositis. RECENT FINDINGS Interferon-alpha and beta are implicated in the innate immune responses underlying dermatomyositis, whereas interferon-gamma stands forward as a more general… CONTINUE READING
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