Role of cytokines (TNF-α, IL-1β and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide

@article{Melo2007RoleOC,
  title={Role of cytokines (TNF-α, IL-1β and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide},
  author={Maria Luisa P. Melo and Gerly Anne Casto Brito and Rudy C. Soares and Sarah B. L. M. Carvalho and J. Villalobos Silva and Pedro Marcos Gomes Soares and Mariana Lima Vale and Marcellus Henrique Loiola Pontes de Souza and Fernando Q Cunha and Ronaldo de Albuquerque Ribeiro},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2007},
  volume={61},
  pages={775-784}
}
Irinotecan (CPT-11) is an inhibitor of DNA topoisomerase I and is clinically effective against several cancers. A major toxic effect of CPT-11 is delayed diarrhea; however, the exact mechanism by which the drug induces diarrhea has not been established. Elucidate the mechanisms of induction of delayed diarrhea and determine the effects of the cytokine production inhibitor pentoxifylline (PTX) and thalidomide (TLD) in the experimental model of intestinal mucositis, induced by CPT-11. Intestinal… CONTINUE READING

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