Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane.

  title={Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane.},
  author={J. Villalba and F. Navarro and C. G{\'o}mez-D{\'i}az and A. Arroyo and R. Bello and P. Navas},
  journal={Molecular aspects of medicine},
  volume={18 Suppl},
  • J. Villalba, F. Navarro, +3 authors P. Navas
  • Published 1997
  • Biology, Medicine
  • Molecular aspects of medicine
  • Cytochrome b5 reductase purified from liver plasma membrane reduces coenzyme Q (CoQ) in reconstituted liposomes in the absence of cytochrome b5. Both CoQ and its reductase are responsible for the reduction of the ascorbate free radical at the cell surface. Thus, NADH-CoQ reductase represents a partial reaction of NADH-AFR reductase in the plasma membrane. Cytochrome b5 reductase maintains CoQ and ascorbate in their reduced state to support antioxidations. Reduced CoQ prevents lipid peroxidation… CONTINUE READING
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