Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane.

@article{Villalba1997RoleOC,
  title={Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane.},
  author={Jos{\'e} Manuel Soto Villalba and Francisco Frechina Navarro and Consuelo G{\'o}mez-D{\'i}az and Antonio S. Mart{\'i}n Arroyo and Rosario I. Bello and Pl{\'a}cido Navas},
  journal={Molecular aspects of medicine},
  year={1997},
  volume={18 Suppl},
  pages={
          S7-13
        }
}
Cytochrome b5 reductase purified from liver plasma membrane reduces coenzyme Q (CoQ) in reconstituted liposomes in the absence of cytochrome b5. Both CoQ and its reductase are responsible for the reduction of the ascorbate free radical at the cell surface. Thus, NADH-CoQ reductase represents a partial reaction of NADH-AFR reductase in the plasma membrane. Cytochrome b5 reductase maintains CoQ and ascorbate in their reduced state to support antioxidations. Reduced CoQ prevents lipid peroxidation… CONTINUE READING

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