Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth

@inproceedings{David2013RoleOC,
  title={Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth},
  author={J Galton David and Hanafy Mahmoud Ismail and Alexia Chandor-Proust and Mark Paine},
  booktitle={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2013}
}
The fight against diseases spread by mosquitoes and other insects has enormous environmental, economic and social consequences. Chemical insecticides remain the first line of defence but the control of diseases, especially malaria and dengue fever, is being increasingly undermined by insecticide resistance. Mosquitoes have a large repertoire of P450s (over 100 genes). By pinpointing the key enzymes associated with insecticide resistance we can begin to develop new tools to aid the… CONTINUE READING

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