Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation.

@article{Loot2008RoleOC,
  title={Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation.},
  author={Annemarieke Elisabeth Loot and R. M. Popp and Beate Fisslthaler and Joris Vriens and Bernd Nilius and Ingrid Fleming},
  journal={Cardiovascular research},
  year={2008},
  volume={80 3},
  pages={445-52}
}
AIMS Fluid shear stress elicits endothelium-dependent vasodilatation via nitric oxide and prostacyclin-dependent and -independent mechanisms. The latter includes the opening of Ca(2+)-operated potassium channels by cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) leading to endothelial hyperpolarization. We previously reported that… CONTINUE READING