Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.

@article{Sacerdoti2003RoleOC,
  title={Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.},
  author={David Sacerdoti and Angelo Gatta and J C Mcgiff},
  journal={Prostaglandins & other lipid mediators},
  year={2003},
  volume={72 1-2},
  pages={51-71}
}
Arachidonic acid (AA) can undergo monooxygenation or epoxidation by enzymes in the cytochrome P450 (CYP) family in the brain, kidney, lung, vasculature, and the liver. CYP-AA metabolites, 19- and 20-hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) and diHETEs have different biological properties based on sites of production and can be stored in tissue lipids and released in response to hormonal stimuli. 20-HETE is a vasoconstrictor, causing blockade of Ca(++)-activated K… CONTINUE READING
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