Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor.

@article{Chiba1996RoleOC,
  title={Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor.},
  author={Masato Chiba and M Hensleigh and J A Nishime and Suresh K. Balani and Jiunn Huei Lin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1996},
  volume={24 3},
  pages={307-14}
}
MK-639 (L-735,524) is a potent human immunodeficiency virus protease inhibitor under investigation in the treatment of acquired immunodeficiency syndrome. Five in vitro approaches have been used to identify the cytochrome P450 isoform(s) responsible for the human microsomal oxidative metabolism of MK-639. These approaches are: 1) chemical inhibition; 2) immunochemical inhibition; 3) metabolism by cDNA-expressed human cytochrome P450 enzymes; 4) a correlation analysis; and 5) competitive… CONTINUE READING

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