Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin.

@article{Haritos2000RoleOC,
  title={Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin.},
  author={Victoria S Haritos and H Ghabrial and Jorma T. Ahokas and Michael S. Ching},
  journal={Pharmacogenetics},
  year={2000},
  volume={10 7},
  pages={
          591-603
        }
}
  • Victoria S Haritos, H Ghabrial, +1 author Michael S. Ching
  • Published 2000
  • Biology, Medicine
  • Pharmacogenetics
  • The tricyclic antidepressant, doxepin, is formulated as an irrational mixture of E (trans) and Z (cis) stereoisomers (85%: 15%). We examined the stereoselective metabolism of doxepin in vitro, with the use of human liver microsomes, recombinant CYP2D6 and gas chromatography-mass spectrometry. In human liver microsomes over the concentration range 5-1500 microM, the rate of Z-doxepin N-demethylation exceeded that of E-doxepin above 100 microM in two of three livers. Eadie-Hofstee plots were… CONTINUE READING

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