Role of cytochrome P-450 IIE1 and catalase in the oxidation of acetonitrile to cyanide.

@article{Feierman1989RoleOC,
  title={Role of cytochrome P-450 IIE1 and catalase in the oxidation of acetonitrile to cyanide.},
  author={Dennis E Feierman and Arthur I. Cederbaum},
  journal={Chemical research in toxicology},
  year={1989},
  volume={2 6},
  pages={359-66}
}
Acetonitrile is a common industrial solvent and laboratory agent, which can be toxic if ingested. The toxicity of nitriles appears to be due to the production of cyanide, and detailed studies by Freeman and Hayes [(1988) Biochem. Pharmacol. 37, 1153-1159; (1987) Fundam. Appl. Toxicol. 8, 263-271] have shown that microsomes oxidize acetonitrile to cyanide. Treatment of rats with inducers of cytochrome P-450 IIE1 such as pyrazole, 4-methylpyrazole, and ethanol resulted in a 4- to 5-fold increase… CONTINUE READING

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