Role of cysteine and taurine in regulating glutathione synthesis by periportal and perivenous hepatocytes.

@article{Penttil1990RoleOC,
  title={Role of cysteine and taurine in regulating glutathione synthesis by periportal and perivenous hepatocytes.},
  author={Kai E Penttil{\"a}},
  journal={The Biochemical journal},
  year={1990},
  volume={269 3},
  pages={659-64}
}
The uptake and metabolism of 35S-labelled sulphur amino acids were compared in periportal (PP) and perivenous (PV) rat hepatocytes, isolated by digitonin/collagenase perfusion, to identify the factors underlying the previously observed [Kera, Penttilä & Lindros, Biochem. J. (1988) 254, 411-417] higher rate of GSH replenishment in PP cells. The buthionine sulphoximine-inhibitable synthesis of GSH was faster in PP than in PV hepatocytes with both cysteine (6.1 versus 5.0 mumol/h per g of cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…