Role of cyclophilin B in activation of interferon regulatory factor-3.

  title={Role of cyclophilin B in activation of interferon regulatory factor-3.},
  author={Yoko Obata and Kazuo Yamamoto and Masanobu Miyazaki and Kunitada Shimotohno and Shigeru Kohno and Toshifumi Matsuyama},
  journal={The Journal of biological chemistry},
  volume={280 18},
IRF-3 is a member of the interferon regulatory factors (IRFs) and plays a principal role in the induction of interferon-beta (IFN-beta) by virus infection. Virus infection results in the phosphorylation of IRF-3 by IkappaB kinase epsilon and TANK-binding kinase 1, leading to its dimerization and association with the coactivators CREB-binding protein/p300. The IRF-3 holocomplex translocates to the nucleus, where it induces IFN-beta. In the present study, we examined the molecular mechanism of… CONTINUE READING


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