Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis.

@article{Patil2009RoleOC,
  title={Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis.},
  author={Mohini A Patil and Susie A Lee and Everardo Macias and Ernest T. Lam and Chuanrui Xu and Kirk D. Jones and Coral Ho and Marcelo L. Rodriguez-Puebla and Xin Mao Chen},
  journal={Cancer research},
  year={2009},
  volume={69 1},
  pages={253-61}
}
Activation of c-Met signaling and beta-catenin mutations are frequent genetic events observed in liver cancer development. Recently, we demonstrated that activated beta-catenin can cooperate with c-Met to induce liver cancer formation in a mouse model. Cyclin D1 (CCND1) is an important cell cycle regulator that is considered to be a downstream target of beta-catenin. To determine the importance of CCND1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis, we investigated the… CONTINUE READING
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