Role of cyclic GMP in gene regulation.

  title={Role of cyclic GMP in gene regulation.},
  author={Renate B Pilz and Kate E Broderick},
  journal={Frontiers in bioscience : a journal and virtual library},
Cyclic GMP is produced in response to nitric oxide and natriuretic peptides; cGMP is a key regulator of cell proliferation, differentiation, and apoptosis, and plays an important role in many (patho)physiological processes such as synaptic plasticity, angiogenesis, inflammation, and cardiac hypertrophy. The regulation of gene expression by cGMP has been recognized relatively recently, but cGMP-mediated increases or decreases in the mRNA expression of >60 different genes have been described, and… CONTINUE READING
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