Role of cross-talk between IFN-alpha-induced monocyte-derived dendritic cells and NK cells in priming CD8+ T cell responses against human tumor antigens.

@article{Tosi2004RoleOC,
  title={Role of cross-talk between IFN-alpha-induced monocyte-derived dendritic cells and NK cells in priming CD8+ T cell responses against human tumor antigens.},
  author={Diego Tosi and Roberta Valenti and Agata Cova and Gloria Sovena and Veronica Huber and Lorenzo Pilla and Flavio Arienti and Filippo Belardelli and Giorgio Parmiani and Licia Rivoltini},
  journal={Journal of immunology},
  year={2004},
  volume={172 9},
  pages={5363-70}
}
In the present study we evaluated the role of IFN-alpha in the generation of dendritic cells (IFN-DCs) with priming activity on CD8(+) T lymphocytes directed against human tumor Ags. A 3-day treatment of monocytes, obtained as adherent PBMCs from HLA-A*0201(+) healthy donors, with IFN-alpha and GM-CSF led to the differentiation of DCs displaying a semimature phenotype, but promptly inducing CD8(+) T cell responses after one in vitro sensitization with peptides derived from melanoma (gp100(209… CONTINUE READING