Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation

@article{Fukudo2006RoleOC,
  title={Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation},
  author={S. Fukudo},
  journal={Journal of Gastroenterology},
  year={2006},
  volume={42},
  pages={48-51}
}
  • S. Fukudo
  • Published 2006
  • Medicine
  • Journal of Gastroenterology
  • Corticotropin-releasing hormone (CRH) is a major mediator of stress response in the brain-gut axis. Irritable bowel syndrome (IBS) is presumed to be a disorder of the brain–gut link associated with exaggerated response to stress. We first showed that peripheral administration of CRH aggravated visceral sensorimotor function as well as adrenocorticotropic hormone (ACTH) response in IBS patients. We then administered α-helical CRH (αhCRH), a non-selective CRH receptor antagonist among IBS… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 97 CITATIONS, ESTIMATED 53% COVERAGE

    Corticotropin-Releasing Hormone Receptor 1 Gene Variants in Irritable Bowel Syndrome

    VIEW 3 EXCERPTS
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2008
    2019

    CITATION STATISTICS

    • 6 Highly Influenced Citations

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 32 REFERENCES

    Stress-induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells.