Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation

@article{Fukudo2006RoleOC,
  title={Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation},
  author={Shin Fukudo},
  journal={Journal of Gastroenterology},
  year={2006},
  volume={42},
  pages={48-51}
}
  • S. Fukudo
  • Published 19 January 2007
  • Biology, Medicine
  • Journal of Gastroenterology
Corticotropin-releasing hormone (CRH) is a major mediator of stress response in the brain-gut axis. Irritable bowel syndrome (IBS) is presumed to be a disorder of the brain–gut link associated with exaggerated response to stress. We first showed that peripheral administration of CRH aggravated visceral sensorimotor function as well as adrenocorticotropic hormone (ACTH) response in IBS patients. We then administered α-helical CRH (αhCRH), a non-selective CRH receptor antagonist among IBS… 

Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome

Impaired top-down inhibitory input from the pregenual ACC to the HPA axis may lead to altered neuroendocrine and gastrointestinal responses to CRH, and centrally acting treatments may dampen the stress induced physical symptoms in IBS.

A role for corticotropin-releasing factor in functional gastrointestinal disorders

Preclinical studies show that activation of the CRF1 receptor by exogenous CRF or stress recapitulates many functional symptoms of IBS diarrhea-predominant patients as related to anxiogenic/hypervigilant behavior, autonomic nervous system alterations, induction of diarrhea, visceral hyperalgesia, enhanced colonic motility, mucus secretion, increased permeability, bacterial translocation, and mast cell activation, which are all alleviated by selective CRF 1 receptor antagonists.

Impaired emotional learning and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome.

Although CRF signaling via CRF-R1 is involved in fear acquisition and extinction learning related to expected abdominal pain in patients with IBS and controls, this system appears to be up-regulated in patientswith IBS, which might contribute to the previously reported abnormal brain responses to expected abdomen pain.

Corticotropin-Releasing Hormone Receptor 1 Gene Variants in Irritable Bowel Syndrome

It is suggested that genetic polymorphisms and the CRH-R1 haplotypes moderate IBS and related bowel patterns and negative emotion accompanying IBS.

The Brain-Gut Axis in the Pathophysiology of Irritable Bowel Syndrome

Visceral hypersensitivity is considered to be the mutual and final result of a multiple level dysregulation of the brain-gut axis in patients with functional gastrointestinal disorders.

Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome

It was found that mucosal eosinophils displayed higher degranulation profile in IBS-D as compared to HC, with increased content of CRF in the cytoplasmic granules, which significantly correlated with IBS clinical severity, life stress background and depression.

Altered Psychobiological Responsiveness in Women With Irritable Bowel Syndrome

The enhanced morning cortisol levels in one subgroup of IBS patients may indicate an association between basal HPA axis activity and predominant bowel habit and all subjective stress ratings were increased in the IBS group, which may indicate increased stress susceptibility.

Upregulation of the high-affinity choline transporter in colon relieves stress-induced hyperalgesia

CHT1 may exert an antinociceptive effect in stress-induced visceral pain by modulating ACh synthesis through nuclear factor kappa B signaling and could be used as a potential drug to treat disorders with hyperalgesia.

Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission

The role of the enteric nervous system in IBS appearance and evolution and as a possible target of drug therapies is emphasized.
...

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