Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation

@article{Fukudo2006RoleOC,
  title={Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation},
  author={S. Fukudo},
  journal={Journal of Gastroenterology},
  year={2006},
  volume={42},
  pages={48-51}
}
  • S. Fukudo
  • Published 2006
  • Medicine
  • Journal of Gastroenterology
Corticotropin-releasing hormone (CRH) is a major mediator of stress response in the brain-gut axis. Irritable bowel syndrome (IBS) is presumed to be a disorder of the brain–gut link associated with exaggerated response to stress. We first showed that peripheral administration of CRH aggravated visceral sensorimotor function as well as adrenocorticotropic hormone (ACTH) response in IBS patients. We then administered α-helical CRH (αhCRH), a non-selective CRH receptor antagonist among IBS… Expand
Corticotropin-Releasing Hormone Receptor 1 Gene Variants in Irritable Bowel Syndrome
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