Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation

@article{Fukudo2006RoleOC,
  title={Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation},
  author={Shin Fukudo},
  journal={Journal of Gastroenterology},
  year={2006},
  volume={42},
  pages={48-51}
}
  • S. Fukudo
  • Published 19 January 2007
  • Biology, Medicine
  • Journal of Gastroenterology
Corticotropin-releasing hormone (CRH) is a major mediator of stress response in the brain-gut axis. Irritable bowel syndrome (IBS) is presumed to be a disorder of the brain–gut link associated with exaggerated response to stress. We first showed that peripheral administration of CRH aggravated visceral sensorimotor function as well as adrenocorticotropic hormone (ACTH) response in IBS patients. We then administered α-helical CRH (αhCRH), a non-selective CRH receptor antagonist among IBS… 

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Visceral hypersensitivity is considered to be the mutual and final result of a multiple level dysregulation of the brain-gut axis in patients with functional gastrointestinal disorders.

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TLDR
The enhanced morning cortisol levels in one subgroup of IBS patients may indicate an association between basal HPA axis activity and predominant bowel habit and all subjective stress ratings were increased in the IBS group, which may indicate increased stress susceptibility.

Upregulation of the high-affinity choline transporter in colon relieves stress-induced hyperalgesia

TLDR
CHT1 may exert an antinociceptive effect in stress-induced visceral pain by modulating ACh synthesis through nuclear factor kappa B signaling and could be used as a potential drug to treat disorders with hyperalgesia.

Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission

TLDR
The role of the enteric nervous system in IBS appearance and evolution and as a possible target of drug therapies is emphasized.

Neonatal maternal separation elevates thalamic corticotrophin releasing factor type 1 receptor expression response to colonic distension in rat.

TLDR
The results suggested an up-regulation of thalamus CRF-R1 is associated with visceral hyperalgesia in the rat model of NMS, which is an essential factor contributing to the development of irritable bowel syndrome.
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