Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation

  title={Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation},
  author={Shin Fukudo},
  journal={Journal of Gastroenterology},
  • S. Fukudo
  • Published 19 January 2007
  • Biology, Medicine
  • Journal of Gastroenterology
Corticotropin-releasing hormone (CRH) is a major mediator of stress response in the brain-gut axis. Irritable bowel syndrome (IBS) is presumed to be a disorder of the brain–gut link associated with exaggerated response to stress. We first showed that peripheral administration of CRH aggravated visceral sensorimotor function as well as adrenocorticotropic hormone (ACTH) response in IBS patients. We then administered α-helical CRH (αhCRH), a non-selective CRH receptor antagonist among IBS… 

Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome

Impaired top-down inhibitory input from the pregenual ACC to the HPA axis may lead to altered neuroendocrine and gastrointestinal responses to CRH, and centrally acting treatments may dampen the stress induced physical symptoms in IBS.

A role for corticotropin-releasing factor in functional gastrointestinal disorders

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Impaired emotional learning and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome.

Although CRF signaling via CRF-R1 is involved in fear acquisition and extinction learning related to expected abdominal pain in patients with IBS and controls, this system appears to be up-regulated in patientswith IBS, which might contribute to the previously reported abnormal brain responses to expected abdomen pain.

Corticotropin-Releasing Hormone Receptor 1 Gene Variants in Irritable Bowel Syndrome

It is suggested that genetic polymorphisms and the CRH-R1 haplotypes moderate IBS and related bowel patterns and negative emotion accompanying IBS.

The Brain-Gut Axis in the Pathophysiology of Irritable Bowel Syndrome

Visceral hypersensitivity is considered to be the mutual and final result of a multiple level dysregulation of the brain-gut axis in patients with functional gastrointestinal disorders.

Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome

It was found that mucosal eosinophils displayed higher degranulation profile in IBS-D as compared to HC, with increased content of CRF in the cytoplasmic granules, which significantly correlated with IBS clinical severity, life stress background and depression.

Altered Psychobiological Responsiveness in Women With Irritable Bowel Syndrome

The enhanced morning cortisol levels in one subgroup of IBS patients may indicate an association between basal HPA axis activity and predominant bowel habit and all subjective stress ratings were increased in the IBS group, which may indicate increased stress susceptibility.

Upregulation of the high-affinity choline transporter in colon relieves stress-induced hyperalgesia

CHT1 may exert an antinociceptive effect in stress-induced visceral pain by modulating ACh synthesis through nuclear factor kappa B signaling and could be used as a potential drug to treat disorders with hyperalgesia.

Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission

The role of the enteric nervous system in IBS appearance and evolution and as a possible target of drug therapies is emphasized.



Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome

Peripheral administration of α-helical CRH improves gastrointestinal motility, visceral perception, and negative mood in response to gut stimulation, without affecting the hypothalamo-pituitary-adrenal axis in IBS patients.

Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome

Human intestinal motility is probably modulated by exogenous CRH, and the brain-gut in IBS patients may have an exaggerated response to CRH.

Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?

IBS is characterized by an overactivation of the hypothalamic-pituitary-adrenal axis and a proinflammatory cytokine increase.

Brain-gut response to stress and cholinergic stimulation in irritable bowel syndrome. A preliminary study.

The results suggest that patients with IBS have exaggerated responsivity of the gut and the brain to mental stress and cholinergic stimulation, and there is a possibility that these exaggerated responses are related.

Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats.

It is suggested that JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats.

Stress‐induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells

Study of the influence of partial restraint stress on the abdominal cramps induced by rectal distension in rats and the role of corticotropin releasing factor (CRF) and mast cells degranulation in this response found pathways involving central CRF and intestinal mast cells involved.

Role of CRF in Stress‐Related Alterations of Gastric and Colonic Motor Function a

The demonstration that central CRF plays a role in mediating gastric stasis resulting from surgery, peritonitis or high levels of central interleukin-1 provides new insight into the mechanisms involved in gastric ileus induced postoperatively or by infectious disease.

Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor

Treatment with SCP or SRP suppressed food intake, delayed gastric emptying and decreased heat-induced edema, and could allow the design of drugs to ameliorate stress-related diseases.

Postinfectious irritable bowel syndrome.

A small but significant subgroup of patients with irritable bowel syndrome (IBS) report a sudden onset of their IBS symptoms after a bout of gastroenteritis, and some preliminary human data suggest this leads to excessive serotonin release from the mucosa.