Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice.

@article{Baumgarten2008RoleOC,
  title={Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice.},
  author={Louisa von Baumgarten and Raimund Trabold and Serge Thal and Tobias Back and Nikolaus Plesnila},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2008},
  volume={28 7},
  pages={1353-60}
}
In recent years, several studies have unequivocally shown the occurrence of cortical spreading depressions (CSDs) after stroke and traumatic brain injury (TBI) in humans. The fundamental question, however, is whether CSDs cause or result from secondary brain damage. The aim of the current study was, therefore, to investigate the role of CSDs for secondary brain damage in an experimental model of TBI. C57/BL6 mice were traumatized by controlled cortical impact. Immediately after trauma, each… CONTINUE READING