Role of coreceptors in positive selection and lineage commitment.

Abstract

Recent experiments have re-awakened interest in a stochastic/selective model of positive selection of T lymphocytes. A revised version of the model has been proposed whereby commitment of double-positive thymocytes to either the CD4 or CD8 lineage requires two engagements with MHC molecules: the first, initiating the differentiation program, signals down… (More)

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@article{Chan1994RoleOC, title={Role of coreceptors in positive selection and lineage commitment.}, author={S. H. Chan and Caroline Waltzinger and A. Baron and C. Benoist and Diane Mathis}, journal={The EMBO journal}, year={1994}, volume={13 19}, pages={4482-9} }