Role of copper gluconate/triethanolamine in irinotecan encapsulation inside the liposomes.

@article{Dicko2007RoleOC,
  title={Role of copper gluconate/triethanolamine in irinotecan encapsulation inside the liposomes.},
  author={Awa Dicko and Paul G. Tardi and Xiaowei Xie and Lawrence D. Mayer},
  journal={International journal of pharmaceutics},
  year={2007},
  volume={337 1-2},
  pages={
          219-28
        }
}
A novel method for encapsulating irinotecan into liposomes containing copper gluconate buffered to pH 7.0 with triethanolamine (TEA) has recently been developed. In the present study, the mechanism dictating drug encapsulation and retention inside those liposomes was investigated. Spectroscopic analyses revealed that irinotecan interacted with copper gluconate/TEA in solution. Fourier transformed infrared (FT-IR) spectroscopy indicated a strengthening of the hydrogen bonds involving the… Expand
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