Role of copper and manganese in prion disease progression.

  title={Role of copper and manganese in prion disease progression.},
  author={Gerda Mitteregger and Stefan Korte and Mehdi Shakarami and Jochen Herms and Hans A. Kretzschmar},
  journal={Brain research},
The cellular prion protein (PrP(C)), a copper binding protein has a primary role in the pathogenesis of in prion diseases. In these diseases alterations in the levels of copper and manganese have been described but how these alterations are involved in the pathogenesis is still unknown. Here we analysed synaptosomes of scrapie infected mice and observed a significant reduction in the amount of copper and an increase of the manganese content at day 100 after infection. Moreover a reduction of… CONTINUE READING
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