Role of constitutively expressed heme oxygenase-2 in the regulation of guinea pig coronary artery tone

@article{Gagov2003RoleOC,
  title={Role of constitutively expressed heme oxygenase-2 in the regulation of guinea pig coronary artery tone},
  author={Hristo S Gagov and Boris Kadinov and Kiril L. Hristov and Kiril K. Boev and Dimiter Itzev and Thomas B. Bolton and Dessislava B. Duridanova},
  journal={Pfl{\"u}gers Archiv},
  year={2003},
  volume={446},
  pages={412-421}
}
Carbon monoxide (CO) is well known as a relaxing substance in the vasculature, where it is released during the heme oxygenase (HO) reaction. Little is known about the tissue-specific targets of CO in smooth muscles. To date the functional role of CO in the coronary artery remains unclear. The expression of HO-2, the constitutive isoform of HO, but not of HO-1 (inducible HO isoform) was demonstrated by immunohistochemical reaction. Contractile studies, performed under isometrical conditions… 
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TLDR
In heme-arginate-treated SD rats, the HO system was potentiated to a lesser magnitude and the suppression of ET-1, PLC, IP3 and NF-κB were less accentuated, suggesting greater selectivity of HO against the ET- 1–PLC–IP3–NF-κBs destructive axis in the pathological condition of mineralocorticoid-induced hypertension.
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