Role of constituents of Optison in Optison-mediated gene transfection enhancement in skeletal muscle in vivo.

@article{Wang2011RoleOC,
  title={Role of constituents of Optison in Optison-mediated gene transfection enhancement in skeletal muscle in vivo.},
  author={Xing-hua Wang},
  journal={Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine},
  year={2011},
  volume={30 3},
  pages={325-32}
}
  • Xing-hua Wang
  • Published 2011 in
    Journal of ultrasound in medicine : official…
OBJECTIVES The mechanism by which Optison (an albumin-shelled, octafluoropropane gas-filled microbubble contrast agent; Amersham Health, Amersham, England) enhances gene transfection in skeletal muscle in vivo with or without ultrasound (US) is unclear. The possible mechanisms were investigated by experimenting with different constituents, both with and without US. METHODS Plasmid DNA (10 μg) encoding green fluorescent protein was mixed with Optison or its constituents dissolved in saline (in… CONTINUE READING

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