Role of conserved hydrophobic amino acids in androgen receptor AF-1 function.

@article{Betney2003RoleOC,
  title={Role of conserved hydrophobic amino acids in androgen receptor AF-1 function.},
  author={Russell Betney and Iain Joseph McEwan},
  journal={Journal of molecular endocrinology},
  year={2003},
  volume={31 3},
  pages={427-39}
}
The intracellular androgen receptor (AR) is a ligand-activated transcription factor. Upon binding the steroids testosterone or dihydrotestosterone, the activated receptor translocates to the nucleus, binds to specific DNA response elements and interacts with the transcription machinery in order to regulate gene transcription. In the present study, we have described a highly conserved region (amino acids 224-258) within the AR AF-1 domain and have investigated the role of conserved bulky… CONTINUE READING