Role of connexin 43 in ischemic preconditioning does not involve intercellular communication through gap junctions.

@article{Li2004RoleOC,
  title={Role of connexin 43 in ischemic preconditioning does not involve intercellular communication through gap junctions.},
  author={Xiaohai Li and Frank Heinzel and Kerstin Boengler and Richard Schulz and Gerd Heusch},
  journal={Journal of molecular and cellular cardiology},
  year={2004},
  volume={36 1},
  pages={161-3}
}
Connexin 43 (Cx 43) has recently been implicated in protection of ischemic preconditioning. Cx 43 colocalization with protein kinase C and p38 mitogen-activated protein kinase is increased in preconditioned myocardium, Cx 43 phosphorylation is preserved in preconditioned myocardium, and hearts from Cx 43-deficient mice cannot be preconditioned. It is, however, unclear whether the important role of Cx 43 relates to intercellular communication through gap junctions or its function in volume… CONTINUE READING
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