Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy.

@article{Wahab2001RoleOC,
  title={Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy.},
  author={Nadia Abdel Wahab and Natalia Yu. Yevdokimova and Benjamin S Weston and Terry P Roberts and Xiu Juan Li and H. Brinkman and Roger M. Mason},
  journal={The Biochemical journal},
  year={2001},
  volume={359 Pt 1},
  pages={77-87}
}
We characterized a rabbit polyclonal antibody raised against human recombinant connective tissue growth factor (CTGF). The antibody recognised a higher molecular mass form (approx. 56 kDa) of CTGF in mesangial cell lysates as well as the monomeric (36-38 kDa) and lower molecular mass forms (<30 kDa) reported previously. Immunohistochemistry detected CTGF protein in glomeruli of kidneys of non-obese diabetic mice 14 days after the onset of diabetes, and this was prominent by 70 days. CTGF… CONTINUE READING