Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis.

@article{Yokoi2002RoleOC,
  title={Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis.},
  author={Hideki Yokoi and Masashi Mukoyama and Akira Sugawara and Kiyoshi Mori and Tetsuya Nagae and Hisashi Makino and Takayoshi Suganami and Kensei Yahata and Yuriko Fujinaga and Issei Tanaka and Kazuwa Nakao},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={282 5},
  pages={
          F933-42
        }
}
Connective tissue growth factor (CTGF) is one of the candidate factors mediating downstream events of transforming growth factor-beta (TGF-beta), but its role in fibrogenic properties of TGF-beta and in tubulointerstitial fibrosis has not yet been clarified. Using unilateral ureteral obstruction (UUO) in rats, we analyzed gene expression of TGF-beta1, CTGF, and fibronectin. We further investigated the effect of blockade of endogenous CTGF on TGF-beta-induced fibronectin expression in cultured… CONTINUE READING

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