Role of complex nucleosides in the reversal of oxidative stress and metabolic disorders induced by acute nitrite poisoning

@inproceedings{Gonchar2006RoleOC,
  title={Role of complex nucleosides in the reversal of oxidative stress and metabolic disorders induced by acute nitrite poisoning},
  author={Oleksiy Gonchar and Irina N. Mankovskaya and E. Klyuchko},
  year={2006}
}
Objective: To investigate the possible mechanisms of splenozide influence on oxidative stress and metabolic disorders in tissues caused by acute nitrite intoxication in rats. Materials and Methods: Nitrite poisoning (NaNO 2 , 60 mg/kg, s.c.) was induced in rats pretreated with splenozide (natural metabolite, nucleoside complex; 3 mg/kg, i.p.). The parameters of lipid peroxidation (LPO), antioxidant defe se system (superoxide dismutase [SOD], catalase [CAT], glutathione content [GSH… CONTINUE READING

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