Role of complement in the pathogenesis of experimental autoimmune myasthenia gravis

@article{Lennon1978RoleOC,
  title={Role of complement in the pathogenesis of experimental autoimmune myasthenia gravis},
  author={Vanda A. Lennon and Marjorie E. Seybold and Jon M. Lindstrom and Camille Cochrane and Richard J Ulevitch},
  journal={The Journal of Experimental Medicine},
  year={1978},
  volume={147},
  pages={973 - 983}
}
An acute phase of experimental autoimmune myasthenia gravis (EAMG) occurs transiently early in the immune response of Lewis rats to nicotinic acetylcholine receptors (AChR) when Bordetella pertussis is used as adjuvant. It is characterized by a destructive cellular attack directed at the postsynaptic membranes of muscle. Acute EAMG can be passively transferred to normal rats by IgG from serum of rats with chronic EAMG. In the present study, acute EAMG, induced either by passive transfer of… CONTINUE READING

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