Role of colony stimulating factor-1 in brain damage caused by ischemia.

@article{Fedoroff1997RoleOC,
  title={Role of colony stimulating factor-1 in brain damage caused by ischemia.},
  author={Sergey Fedoroff and O. Berezovskaya and Dusica Maysinger},
  journal={Neuroscience and biobehavioral reviews},
  year={1997},
  volume={21 2},
  pages={187-91}
}
A marked effect of colony stimulating factor-1(CSF-1) on microglial response and neuron survival in cerebral cortex ischemic damage was observed. In osteopetrotic op/op mice, which lack systemically functional CSF-1 microglia do not respond to ischemic damage to the cerebral cortex, and the infarcts are considerably larger than in CSF-1 producing mice with similar vascular impairment. Delivery of extraneous CSF-1 to op/op mice alleviates the functional deficiency of the microglia and… CONTINUE READING

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