Role of collagen hydrolysate in bone and joint disease.

@article{Moskowitz2000RoleOC,
  title={Role of collagen hydrolysate in bone and joint disease.},
  author={Roland W. Moskowitz},
  journal={Seminars in arthritis and rheumatism},
  year={2000},
  volume={30 2},
  pages={
          87-99
        }
}
  • R. Moskowitz
  • Published 1 October 2000
  • Medicine
  • Seminars in arthritis and rheumatism
OBJECTIVES To review the current status of collagen hydrolysate in the treatment of osteoarthritis and osteoporosis. METHODS Review of past and current literature relative to collagen hydrolysate metabolism, and assessment of clinical investigations of therapeutic trials in osteoarthritis and osteoporosis. RESULTS Hydrolyzed gelatin products have long been used in pharmaceuticals and foods; these products are generally recognized as safe food products by regulatory agencies. Pharmaceutical… 
View on PubMed
fenixpharma.it
288 Citations
Highly Influential Citations
14
Background Citations
91
Methods Citations
9
Results Citations
2

288 Citations

Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:a review of the literature

A growing body of evidence provides a rationale for the use of collagen hydrolysate for patients with OA and suggests mechanisms that might help patients affected by joint disorders such as OA.

[An overview of the beneficial effects of hydrolysed collagen intake on joint and bone health and on skin ageing].

Clinical studies show that HC continual ingestion helps to reduce and prevent joint pain, bone density loss and skin ageing, and its high level of tolerance and safety make HC ingestion attractive for a long-term use in bone and joint degenerative diseases and in fight against skin ageing.

Oral Administration of Gelatin Hydrolysate Reduces Clinical Signs of Canine Osteoarthritis in a Double-Blind, Placebo-Controlled Trial

A double-blind, placebo-controlled trial with privately owned dogs was carried out to assess the efficacy of a preparation of gelatin hydrolysate in the treatment of osteoarthritis, and it was suggested that a dose of about 2.5% in a dry food would be beneficial for dogs with osteo arthritis.

24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain.

This was the first clinical trial of 24-weeks duration to show improvement of joint pain in athletes who were treated with the dietary supplement collagen hydrolysate and the primary efficacy parameter was the change in the visual analogue scales from baseline during the study phase.

A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort

A significant improvement in knee joint comfort was found as assessed by visual analogue scales to assess pain and the Womac pain subscale, and CH is safe and effective and warrants further consideration as a food ingredient.

A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort

A significant improvement in knee joint comfort was found as assessed by visual analogue scales to assess pain and the Womac pain subscale, and CH is safe and effective and warrants further consideration as a food ingredient.

Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density.

Effect of collagen hydrolysate in articular pain: a 6-month randomized, double-blind, placebo controlled study.

24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain

The primary efficacy parameter was the change in the visual analogue scales from baseline during the study phase in relation to the parameters referring to pain, mobility, and inflammation, which showed statistically significant changes with the dietary supplement collagen hydrolysate.

A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.

The study demonstrated that collagen peptides are potential therapeutic agents as nutritional supplements for the management of osteoarthritis and maintenance of joint health.
...

References

SHOWING 1-10 OF 33 REFERENCES

Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate.

[Postmenopausal osteoporosis. Treatment with calcitonin and a diet rich in collagen proteins].

Administration of 100 u.m. calcitonin twice a week for 24 weeks led to a decline of excretion indicators of bone collagen breakdown products and the effect of treatment must be monitored using these indicators.

High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1 year placebo-controlled trial.

Glucosamine sulphate for the management of arthrosis: a controlled clinical investigation.

A new preparation of pure glucosamine sulphate, in injectable and oral form, was investigated in a controlled clinical trial in patients with osteoarthrosis, and each symptom significantly improved.

Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group.

This large, controlled randomized clinical trial confirms that 5 weekly IA injections of HA (Hyalgan) in patients with OA of the knee are generally well tolerated, provide sustained relief of pain and improved patient function, and were at least as effective with fewer adverse reactions as continuous treatment with naproxen for 26 weeks.

Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee.

Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis.

The efficacy and tolerance of oral glucosamine sulphate were tested against placebo in a prospective double-blind trial in 20 out-patients with established osteoarthrosis and significant alleviation of symptoms was associated with the use of the active drug at the prescribed dose.

Clinical trial of intra-articular injection of sodium hyaluronate in patients with osteoarthritis of the knee.

There were small improvements with both treatments, significant at some assessments and somewhat greater with sodium hyaluronate than placebo, but there were no statistically significant differences between the groups.

Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double blind, placebo controlled multicentre trial. Hyaluronan Multicentre Trial Group.

Patients older than 60 years with knee osteoarthritis and with significant symptoms corresponding to an index of severity of knee disease of 10 or more, comprise the group most likely to benefit from treatment with intra-articular hyaluronan injections.

Intra-articular treatment of knee osteoarthritis. A comparative study between hyaluronic acid and 6-methyl prednisolone acetate.

The efficacy and tolerability of 20 mg of hyaluronic acid were compared in an open, randomized trial with that of 40 mg of 6-methylprednisolone acetate, administering them both by an intra-articular…