Role of cofactors in folding of the blue-copper protein azurin.

@article{WittungStafshede2004RoleOC,
  title={Role of cofactors in folding of the blue-copper protein azurin.},
  author={Pernilla Wittung-Stafshede},
  journal={Inorganic chemistry},
  year={2004},
  volume={43 25},
  pages={7926-33}
}
Many proteins in living cells coordinate cofactors, such as metal ions, to attain their activity. Since the cofactors in such cases often can interact with their corresponding unfolded polypeptides in vitro, it is important to unravel how cofactors modulate protein folding. In this review, I will discuss the role of cofactors in folding of the blue-copper protein Pseudomonas aeruginosa azurin. In the case of both copper (Cu(II) and Cu(I)) and zinc (Zn(II)), the metal can bind to unfolded azurin… CONTINUE READING

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