Role of claudin species–specific dynamics in reconstitution and remodeling of the zonula occludens

@inproceedings{Yamazaki2011RoleOC,
  title={Role of claudin species–specific dynamics in reconstitution and remodeling of the zonula occludens},
  author={Yuji Yamazaki and Reitaro Tokumasu and Hiroshi Kimura and Sachiko Tsukita},
  booktitle={Molecular biology of the cell},
  year={2011}
}
Tight-junction strands, which are organized into the beltlike cell-cell adhesive structure called the zonula occludens (TJ), create the paracellular permselective barrier in epithelial cells. The TJ is constructed on the basis of the zonula adherens (AJ) by polymerized claudins in a process mediated by ZO-1/2, but whether the 24 individual claudin family members play different roles at the TJ is unclear. Here we established a cell system for examining the polymerization of individual claudins… CONTINUE READING

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