Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice.

@article{Shan2010RoleOC,
  title={Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice.},
  author={Jian Cheng Shan and Matthew J. Betzenhauser and Alexander Kushnir and Steven R. Reiken and Albano Carlo Meli and Anetta Wronska and Miroslav Dura and B. X. Chen and Andrew Robert Marks},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 12},
  pages={4375-87}
}
Increased sarcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) progression. Inhibition of this leak is an emerging therapeutic strategy. To explore the role of chronic PKA phosphorylation of RyR2 in HF pathogenesis and treatment, we generated a knockin mouse with aspartic acid replacing serine 2808 (mice are referred to herein as RyR2-S2808D+/+ mice). This mutation mimics constitutive PKA… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 85 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

Similar Papers

Loading similar papers…