Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis.

@article{Elias2014RoleOC,
  title={Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis.},
  author={Peter M Elias and Mary Lou Williams and Eung Ho Choi and Kenneth R. Feingold},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1841 3},
  pages={353-61}
}
X-linked ichthyosis is a relatively common syndromic form of ichthyosis most often due to deletions in the gene encoding the microsomal enzyme, steroid sulfatase, located on the short area of the X chromosome. Syndromic features are mild or unapparent unless contiguous genes are affected. In normal epidermis, cholesterol sulfate is generated by cholesterol sulfotransferase (SULT2B1b), but desulfated in the outer epidermis, together forming a 'cholesterol sulfate cycle' that potently regulates… CONTINUE READING
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X-linked icthyosis

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